Chemistry of Salvia divinorum

Active constituents

     Many terpenoids including Salvinorum-A, Salvinorum-B. This species of Salvia contains no thujone. Loliolide, which is an ant repellent has also been isolated in this plant.

     The primary active constituent is Salvinorin A, sum formula C23H28O8, chemical name (2S,4aR,6aR,7R,9S,10aS,10bR)-methyl9-acetoxy-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-dodecahydro-1H-benzo[f]isochromene-7-carboxylate, molecular mass 432.46 g/mol, melting point 238 - 240 ░C. Unlike most other known psychoactive compounds, Salvinorin A is not an amineŚmeaning it contains no nitrogen functional group. The Salvinorin group of compounds (including Salvinorin A, Salvinorin B and Salvinorin C) are called neoclerodane diterpenoids.

     Extraction and purification of Salvinorin A has been documented but should only be attempted by qualified researchers with experience in chemistry and the proper laboratory equipment. Measurement of safe dosages is difficult and requires a sophisticated analytical balance, due to the extreme quantitative potency of Salvinorin A.

Salvinorin A